| Identification | Back Directory | [Name]
ONO-2920632 | [CAS]
2230296-66-7 | [Synonyms]
ONO-2920632
[1,2,4]Triazolo[1,5-a]pyridine-6-carboxamide, N-[[2-fluoro-4-(trifluoromethoxy)phenyl]methyl]- | [MOL File]
2230296-66-7.mol | [Molecular Weight]
354.26 |
| Chemical Properties | Back Directory | [density ]
1.513±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
DMSO: Soluble: = 10 mg/ml
Ethanol: Slightly soluble: 0.1-1 mg/ml | [pka]
11.248±0.46(predicted) |
| Hazard Information | Back Directory | [Description]
ONO-2920632 is an activator of two-pore domain potassium channel 2.1 (K2P2.1/TREK-1) and K2P10.1/TREK-2.1 It induces K2P2.1/TREK-1 and K2P10.1/TREK-2 activity in thallium flux assays using CHO cells expressing K2P2.1/TREK-1 and HEK293 cells expressing K2P10.1/TREK-2 (EC50s = 2.8 and 0.3 µM, respectively). ONO-2920632 is selective for K2P2.1/TREK-1 and K2P10.1/TREK-2 over 72 other ion channels, G protein-coupled receptors (GPCRs), transporters, and nuclear hormones at 10 µM. In vivo, ONO-2920632 (3 mg/kg) prevents acetic acid-induced writhing in mice.WARNING This product is not for human or veterinary use. | [References]
[1] KENTARO YASHIRO, CRAIG W. LINDSLEY* Discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator In Vivo Tool Compound[J]. ACS Chemical Neuroscience, 2025, 16 5: 960-967 960-967. DOI: 10.1021/acschemneuro.5c0003210.1021/acschemneuro.5c00032 |
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