| Identification | Back Directory | [Name]
2-Propen-1-one, 1-[4-[5-chloro-6-(2-chloro-5-hydroxyphenyl)-7-fluoro-2,1-benzisothiazol-3-yl]-1-piperazinyl]- | [CAS]
2230873-67-1 | [Synonyms]
KRAS inhibitor-16
2-Propen-1-one, 1-[4-[5-chloro-6-(2-chloro-5-hydroxyphenyl)-7-fluoro-2,1-benzisothiazol-3-yl]-1-piperazinyl]- | [Molecular Formula]
C20H16Cl2FN3O2S | [MOL File]
2230873-67-1.mol | [Molecular Weight]
452.33 |
| Hazard Information | Back Directory | [Uses]
KRAS inhibitor-16 (compound 3-11) is a potent KRAS G12C inhibitor with an IC50 of 0.457 μM. KRAS inhibitor-16 shows p-ERK inhibition activities with IC50s of 3.06, 11.1 μM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-16 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. | [IC 50]
KRas G12C: 0.457 μM (IC50) | [References]
[1] Brian Alan LANMAN, et al. Kras g12c inhibitors and methods of using the same. US20180334454A1. |
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