| Identification | Back Directory | [Name]
2-Propen-1-one, 1-[4-[6-(5-amino-2-chlorophenyl)-5-chloro-7-fluoro-2,1-benzisothiazol-3-yl]-1-piperazinyl]- | [CAS]
2230873-75-1 | [Synonyms]
KRAS inhibitor-15
2-Propen-1-one, 1-[4-[6-(5-amino-2-chlorophenyl)-5-chloro-7-fluoro-2,1-benzisothiazol-3-yl]-1-piperazinyl]- | [Molecular Formula]
C20H17Cl2FN4OS | [MOL File]
2230873-75-1.mol | [Molecular Weight]
451.34 |
| Hazard Information | Back Directory | [Uses]
KRAS inhibitor-15 (compound 3-19) is a potent KRAS G12C inhibitor with an IC50 of 0.954 μM. KRAS inhibitor-15 shows p-ERK inhibition activities with IC50s of 2.03, >33.3 μM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-15 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. | [IC 50]
KRas G12C: 0.954 μM (IC50) | [References]
[1] Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2 |
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