| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 5-[2-(2-chloroethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)- | [CAS]
2230956-57-5 | [Synonyms]
Thalidomide-5-PEG2-Cl
1H-Isoindole-1,3(2H)-dione, 5-[2-(2-chloroethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)- | [Molecular Formula]
C17H17ClN2O6 | [MOL File]
2230956-57-5.mol | [Molecular Weight]
380.78 |
| Hazard Information | Back Directory | [Uses]
Thalidomide-5-PEG2-Cl is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-PEG2-Cl can be connected to the ligand for protein by a linker to form PROTACs[1]. | [IC 50]
Cereblon | [References]
[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994. DOI:10.1016/j.stem.2020.07.019 |
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