| Identification | Back Directory | [Name]
3-Pyridinecarboxamide, N-[4-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-5-(4-fluorophenyl)-1,4-dihydro-4-oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]- | [CAS]
2231424-62-5 | [Synonyms]
Axl-IN-8
3-Pyridinecarboxamide, N-[4-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-5-(4-fluorophenyl)-1,4-dihydro-4-oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]- | [Molecular Formula]
C31H29FN6O3 | [MOL File]
2231424-62-5.mol | [Molecular Weight]
552.6 |
| Hazard Information | Back Directory | [Uses]
Axl-IN-8 (NO.1) is a potent AXL inhibitor, with an IC50 of <1 nM. Axl-IN-8 also inhibits c-MET, with an IC50 of 1-10 nM. Axl-IN-8 shows anti-proliferative activity against BaF3/TEL-AXL, MKN45, and EBC-1 cells, with IC50 values of <10, 226.6 and 120.3 nM, respectively[1]. | [IC 50]
Axl | [References]
[1] Duan Wenhu, et al. Compound having axl inhibitory activity, preparation method therefor and use thereof. WO2018121228A1. |
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