| Identification | Back Directory | [Name]
MT-802 | [CAS]
2231744-29-7 | [Synonyms]
MT-802
MT802,inhibit,Inhibitor,Btk,Bruton tyrosine kinase,MT-802,MT 802,PROTACs
2-(2-(2-(4-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)acetamide
2-[2-[2-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-
Acetamide, 2-[2-[2-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]- | [Molecular Formula]
C41H41N9O8 | [MDL Number]
MFCD32174275 | [MOL File]
2231744-29-7.mol | [Molecular Weight]
787.82 |
| Hazard Information | Back Directory | [Uses]
MT-802 is a potent BTK degrader based on Cereblon ligand, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL)[1]. | [References]
[1] Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57(26):3564-3575. DOI:10.1021/acs.biochem.8b00391 |
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| Company Name: |
InvivoChem
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| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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