Identification | Back Directory | [Name]
SHR1653 | [CAS]
2231770-73-1 | [Synonyms]
SHR1653 SHR1653,SHR-1653 3-Azabicyclo[3.1.0]hexane, 1-(2-chloro-4-fluorophenyl)-3-[5-(methoxymethyl)-4-(6-methoxy-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-, (1S,5R)- | [Molecular Formula]
C21H21ClFN5O2 | [MDL Number]
MFCD32174297 | [MOL File]
2231770-73-1.mol | [Molecular Weight]
429.88 |
Chemical Properties | Back Directory | [Boiling point ]
577.3±60.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
4.29±0.10(Predicted) | [color ]
Light yellow to yellow |
Hazard Information | Back Directory | [Uses]
SHR1653 is a highly potent, selective and brain penetrated oxytocin receptor (OTR) antagonist, with an IC50 of 15 nM for hOTR[1]. | [storage]
Store at -20°C | [References]
[1] Li X, et al. Discovery of SHR1653, a Highly Potent and Selective OTR Antagonist with Improved Blood-Brain Barrier Penetration. ACS Med Chem Lett. 2019 May 29;10(6):996-1001. DOI:10.1021/acsmedchemlett.9b00186 |
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