| Chemical Properties | Back Directory | [Sequence]
Met-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Pro-Pro-Ser-Lys-Lys-Arg-Ile-Arg-Ile-Gly-Ile-Ala-Gly-Ile-Thr-Ile-Thr-Leu-Ser-Leu-Arg-Pro-Arg-Thr-Ala-Lys-Arg-Arg-Ile-Arg-Leu |
| Hazard Information | Back Directory | [Uses]
Apoptin-derived peptide is an antitumor polypeptide with cytotoxicity. Apoptin-derived peptide promotes apoptosis and necrosis of gastric cancer (GC) cells by regulating PI3K/AKT/ARNT signaling. Apoptin-derived peptide inhibited the invasion and migration of cancer cells, and inhibited the expression and phosphorylation of the subunit p85 of PI3K, which further inhibited the PI3K/AKT pathway involved in the development of gastric cancer[1]. | [References]
[1] Zhou D, et al. Apoptin-derived peptide reverses cisplatin resistance in gastric cancer through the PI3K-AKT signaling pathway [J]. Cancer Medicine, 2018, 7(4): 1369-1383. DOI:10.1002/cam4.1380 |
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Fuan Bio
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