| Identification | Back Directory | [Name]
3H-Pyrazol-3-one, 4-benzoyl-2-(3,4-dimethylphenyl)-1-ethyl-1,2-dihydro-5-methyl- | [CAS]
2232890-81-0 | [Synonyms]
TK4b
3H-Pyrazol-3-one, 4-benzoyl-2-(3,4-dimethylphenyl)-1-ethyl-1,2-dihydro-5-methyl- | [Molecular Formula]
C21H22N2O2 | [MOL File]
2232890-81-0.mol | [Molecular Weight]
334.41 |
| Hazard Information | Back Directory | [Uses]
TK4b is a Janus kinase (JAK) inhibitor with the IC50 values of 19.40 nM and 18.42 nM for JAK2 and JAK3, respectively. TK4b can be used in lymphoid-derived diseases and leukemia cancer research[1]. | [IC 50]
JAK2: 19.40 nM (IC50); JAK3: 18.42 nM (IC50) | [References]
[1] Kamonpan Sanachai, et al. Pharmacophore-Based Virtual Screening and Experimental Validation of Pyrazolone-Derived Inhibitors toward Janus Kinases. ACS Omega 2022. |
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