| Identification | Back Directory | [Name]
SCARA3 | [CAS]
2234275-84-2 | [Synonyms]
CSR
CSR1
APC7
ANAPC7
SCARA3
Anti-CSR
Anti-SEN
Anti-SEN1
Anti-CSRB
Anti-CSR1
Anti-APC7
Anti-MSLR1
Anti-MSRL1
Cyclosome subunit 7
Anti-Mortality factor 4
Rabbit Anti-SCARA3 antibody
Anti-SCARA3 antibody produced in rabbit
Anti-ANAPC7 antibody produced in rabbit
Anti-Anaphase promoting complex subunit 7
Anti-scavenger receptor class A, member 3
Anti-ANAPC7 / APC7 antibody produced in rabbit
Monoclonal Anti-MORF4 antibody produced in mouse
Monoclonal Anti-SCARA3 antibody produced in mouse
2-Pyrimidinamine, N-(2-furanylmethyl)-4-[4-(1H-imidazol-1-yl)phenyl]- | [Molecular Formula]
C18H15N5O | [MOL File]
2234275-84-2.mol | [Molecular Weight]
317.35 |
| Chemical Properties | Back Directory | [Boiling point ]
575.269±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.298±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
-20°C | [form ]
buffered aqueous solution | [pka]
4.858±0.10(predicted) | [biological source]
rabbit |
| Hazard Information | Back Directory | [Uses]
AP-C7 is an inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 5.0. AP-C7 only weakly inhibits cGKII-dependent anion secretion[1]. | [Biological Activity]
Scavenger receptor class A member 3 (SCARA3) protects cells against ultraviolet (UV) irradiation and oxidative stress. Reduced expression of SCARA3 increases oxidative stress in keratoconus (KC) cells in vitro. Quantitative polymerase chain reaction (PCR) analysis proves th at SCARA3 transcript is highly expressed in ovarian/primary peritoneal carcinoma (OC/PPC) compared to breast carcinoma effusions. SCARA3 represses tumor growth and metastasis of prostate cancer. Thereforeit can be used as a potential therapeutic target for treating aggressive types of prostate cancer. | [References]
[1] Marcel J C Bijvelds, et al. Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J Biol Chem. 2018 May 25;293(21):8173-8181. DOI:10.1074/jbc.RA118.002835 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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