| Identification | Back Directory | [Name]
22(R)-HYDROXYCHOLESTEROL | [CAS]
22348-64-7 | [Synonyms]
C05502
22(R)-OH-CH
22BF-HYDROXYCHOLESTEROL
22β-Hydroxy Cholesterol
22(S)-HYDROXYCHOLESTEROL
22BETA-HYDROXYCHOLESTEROL
(5-Cholestene-322(S)-diol)
22-HYDROXYCHOLESTEROL (22R)
22-ALPHA-HYDROXYCHOLESTEROL
Cholest-5-ene-3β,22(S)-diol
(22S)-22-Hydroxycholesterol
CHOLEST-5-ENE-3BETA,22R-DIOL
5-CHOLESTENE-3BETA,22[R]-DIOL
5-CHOLESTENE-3BETA,22[S]-DIOL
5-CHOLESTEN-3-BETA, 22(R)-DIOL
5-CHOLESTEN-3-BETA, 22(S)-DIOL
22ALPHA-DIHYDROXY-5-CHOLESTENE
(22S)-Cholest-5-ene-3β,22-diol
(3β,22S)-Cholest-5-ene-3,22-diol
(20S,22S)-Cholest-5-ene-3β,22-diol
Cholest-5-ene-3,22-diol, (3β,22S)-
3BETA,22BETA-DIHYDROXY-5-CHOLESTENE
22[S]-Hydroxycholesterol (not deuterated)
22β-Hydroxycholesterol, 5-Cholestene-3β,22(S)-diol
CHOLEST-5-ENE-3,22(S)-DIOL;22(S)-HYDROXYCHOLESTEROL
(3S,8S,9S,10R,13R,14S,17R)-17-[(2S,3R)-3-hydroxy-6-methyl-heptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | [Molecular Formula]
C27H46O2 | [MDL Number]
MFCD00010476 | [MOL File]
22348-64-7.mol | [Molecular Weight]
402.65 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 2 mg/ml; DMSO: 0.1 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml | [form ]
A crystalline solid | [InChIKey]
RZPAXNJLEKLXNO-QUOSNDFLSA-N | [SMILES]
O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H]([C@@H](O)CCC(C)C)C)(CC3)C)CC=C2C1)C |
| Hazard Information | Back Directory | [Uses]
The 22S-metabolite of Cholesterol (C432501). 22-Hydroxycholesterol inhibits chemokine receptor activity. | [Definition]
ChEBI: An oxysterol that is the 22S-hydroxy derivative of cholesterol. | [Biological Activity]
22(S)-Hydroxycholesterol modulates the lipid and glucose metabolism by acting on liver X receptors. It has the potential to reduce lipogenesis and the accumulation of lipid in hepatocytesmyotubes and non-adipose tissue. | [in vivo]
Cholest-5-ene-3?,22(S)-diol (30 mg/kg; p.o.; added in diet, treated for 3 weeks) reduces body weight gain and abolishes high-fat diet-induced increase of triacylglycerol (TAG) levels in serum[2].
Pharmacokinetic Analysis in Rats[2]
| Route | Dose (mg/kg) | Cmax (ng/mL) | Tmax (h) | AUCt (ng·h/mL) | AUC (ng·h/mL) | T1/2 (h) | Extent of tritium exchange (%) | | i.v. | 50 | 22.4 | 0.08 | 174 | 195 | 8.1 | 2.8 | | p.o. | 50 | 7.5 | 4 | 95.2 | 104 | 6.4 | 1.2 |
| Animal Model: | Male rats injected with Pentobarbital (20 mg, 50 mg/mL; i.p.)[2] | | Dosage: | 30 mg/kg/day | | Administration: | Oral gavage; 3 weeks consecutively | | Result: | Decreased body weight gain significantly after 1 week treatment.
Increased gene expression of Ucp3 and Cpt2 in liver and skeletal muscle, and increased protein level of Ucp3 in skeletal muscle after 3 weeks treatment. |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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