| Identification | Back Directory | [Name]
HIPPEASTRINE HYDROBROMIDE | [CAS]
22352-41-6 | [Synonyms]
HIPPEASTRINE HBr
(+)-Hippeastrine HBr
HIPPEASTRINE HYDROBROMIDE | [Molecular Formula]
C17H18BrNO5 | [MDL Number]
MFCD00274497 | [MOL File]
22352-41-6.mol | [Molecular Weight]
396.24 |
| Hazard Information | Back Directory | [Description]
Hippeastrine hydrobromide is a natural alkaloid which demonstrates significant cytotoxicity against a panel of human and murine tumor cell lines. | [Uses]
Hippeastrine hydrobromide is an active alkaloid that exhibits a good dose-dependent inhibitory effect on topoisomerase I (Top I) with an IC50 of 7.25?μg/mL. Hippeastrine hydrobromide exhibits antiproliferative and anticancer activities[1]. | [Definition]
ChEBI: Hippeastrine is an indole alkaloid isolated from the Amaryllidaceae family and has been shown to exhibit cytotoxic activity. It has a role as an antineoplastic agent and a metabolite. It is an indole alkaloid, a delta-lactone, a secondary alcohol and an organic heteropentacyclic compound. | [References]
[1] Chen GL, et al. Antiproliferative activities of Amaryllidaceae alkaloids from Lycoris radiata targeting DNA topoisomerase I. Sci Rep. 2016;6:38284. Published 2016 Dec 6. DOI:10.1038/srep38284 |
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