| Identification | Back Directory | [Name]
N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide | [CAS]
223749-46-0 | [Synonyms]
HMR 1556
HMR-1556 >=98% (HPLC)
N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide
Methanesulfonamide, N-[(3R,4S)-3,4-dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methyl- | [Molecular Formula]
C17H24F3NO5S | [MOL File]
223749-46-0.mol | [Molecular Weight]
411.44 |
| Chemical Properties | Back Directory | [Melting point ]
178-179 °C | [Boiling point ]
469.0±55.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
13.30±0.60(Predicted) | [color ]
White to off-white | [Optical Rotation]
[α]/D +2 to +3.5°, c =0.1 in methanol | [InChI]
1S/C17H24F3NO5S/c1-16(2)15(22)14(21(3)27(4,23)24)12-10-11(6-7-13(12)26-16)25-9-5-8-17(18,19)20/h6-7,10,14-15,22H,5,8-9H2,1-4H3/t14-,15+/m0/s1 | [InChIKey]
SRZRLJWUQFIZRH-LSDHHAIUSA-N | [SMILES]
CC1([C@@H]([C@H](C2=CC(OCCCC(F)(F)F)=CC=C2O1)N(C)S(C)(=O)=O)O)C |
| Hazard Information | Back Directory | [Uses]
HMR 1556 is an inhibitor of the slow delayed rectifier potassium current, used in the monitoring and treatment of proarrythmia. | [Biological Activity]
HMR-1556 is a potent and selective blocker of the heteromeric KCNQ1-KCNE1 (KvLQT1-MinK) voltage-gated channel-mediated slowly activating K+ current (IKs IC50 = 120 nM in hKCNE1-transfected Xenopus oocytes; little or no inhibition of HergKv1.3 (KCNA3)Kv1.5 (KCNA5)Kir2.1 (KCNJ2)HCN2 (BCNG2) current in respective oocyte transfectants). HMR-1556 is more potent than chromanol 293B (IKs IC50 = 34 nM and 2.1 μMrespectively; guinea pig ventricular myocytes)being inefficient against L-type Ca2+ channel or rapidly delayed & inward rectifier currents (IKr & IK1) in guinea pig ventricular myocytesnor transient & sustained outward currentsI(to) & I(sus)in r at ventricular myocytes. | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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