| Identification | Back Directory | [Name]
1H-Pyrido[2,1-a]pyrrolo[1,2-c]phthalazine-7-carboxylic acid, 2,3,8,13b-tetrahydro-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-oxo-, (13bR)- | [CAS]
2241575-59-5 | [Synonyms]
HBV-IN-19
1H-Pyrido[2,1-a]pyrrolo[1,2-c]phthalazine-7-carboxylic acid, 2,3,8,13b-tetrahydro-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-oxo-, (13bR)- | [Molecular Formula]
C24H30N2O6 | [MOL File]
2241575-59-5.mol | [Molecular Weight]
442.5 |
| Hazard Information | Back Directory | [Uses]
GS-8873 is an orally active inhibitor for the production of hepatitis B virus (HBV) surface antigen (HBsAg) with an EC50 of 4 nM. GS-8873 exhibits good pharmacokinetic characters in rats and metabolic stability in human hepatocytes. GS-8873 causes neurofunctional deficits in rats and cynomolgus monkeys[1][2]. | [References]
[1] Evangelos Aktoudianakis, et al. Compounds for the treatment of hepatitis b virus infection.WO2018144605A1.
[2] Kato D, et al., Discovery of Hepatitis B Virus Surface Antigen Suppressor GS-8873. ACS Med Chem Lett. 2024 Mar 22;15(4):546-554. DOI:10.1021/acsmedchemlett.4c00037 |
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