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2242542-60-3

2242542-60-3 Structure

2242542-60-3 Structure
IdentificationBack Directory
[Name]

19R(20S)-EpDPA
[CAS]

2242542-60-3
[Synonyms]

19R(20S)-EpDPA
[Molecular Formula]

C22H32O3
[MOL File]

2242542-60-3.mol
[Molecular Weight]

344.49
Chemical PropertiesBack Directory
[Boiling point ]

466.2±33.0 °C(Predicted)
[density ]

0.994±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Ethanol: soluble
[pka]

4.58±0.10(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]


GHS02
[Signal word ]

Danger
Hazard InformationBack Directory
[Uses]

19(R),20(S)-EDP (compound 19(S),20(R)-2a) is an oxylipin and a metabolite of docosahexaenoic acid (HY-B2167)[1].
[Biological Activity]

19R(20S)-EpDPA is an oxylipin and a metabolite of docosahexaenoic acid .1,2 It is formed from DHA by various cytochrome P450 (CYP) isoforms in a stereoselective manner.2 19R(20S)-EpDPA (30 nM) prevents calcium-induced increases in the spontaneous beating of isolated neonatal rat cardiomyocytes (NRCMs).3
[References]

1.Cinelli, M.A., Yang, J., Scharmen, A., et al.Enzymatic synthesis and chemical inversion provide both enantiomers of bioactive epoxydocosapentaenoic acidsJ. Lipid Res.59(11)2237-2252(2018) 2.Lucas, D., Goulitquer, S., Marienhagen, J., et al.Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450J. Lipid Res.51(5)1125-1133(2010) 3.Burke, J.E., and Dennis, E.A.Phospholipase A2 structure/function, mechanism, and signalingJ. Lipid Res.50(Suppl)S237-S242(2009)
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