| Identification | Back Directory | [Name]
Propanamide, N-[6-[3-[(cyclopropylsulfonyl)amino]phenyl]-1H-indazol-3-yl]-2-methyl- | [CAS]
2242913-80-8 | [Synonyms]
Propanamide, N-[6-[3-[(cyclopropylsulfonyl)amino]phenyl]-1H-indazol-3-yl]-2-methyl- | [Molecular Formula]
C20H22N4O3S | [MOL File]
2242913-80-8.mol | [Molecular Weight]
398.48 |
| Chemical Properties | Back Directory | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble to 100 mM in DMSO and to 10 mM in ethanol | [form ]
powder | [pka]
8.78±0.20(Predicted) | [color ]
white to beige | [InChI]
1S/C20H22N4O3S/c1-12(2)20(25)21-19-17-9-6-14(11-18(17)22-23-19)13-4-3-5-15(10-13)24-28(26,27)16-7-8-16/h3-6,9-12,16,24H,7-8H2,1-2H3,(H2,21,22,23,25) | [InChIKey]
RAIAORGFMNXPOV-UHFFFAOYSA-N | [SMILES]
O=C(C(C)C)NC1=NNC2=C1C=CC(C3=CC(NS(C4CC4)(=O)=O)=CC=C3)=C2 |
| Hazard Information | Back Directory | [Uses]
SGC-AAK1-1N is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor, with an IC50 of 1.8 μM[1]. | [Biological Activity]
SGC AAK1 1N is a negative control for SGC AAK1 1 . | [storage]
Store at -20°C | [References]
[1] Wells C, et al. SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K. ACS Med Chem Lett. 2019 Oct 23;11(3):340-345. DOI:10.1021/acsmedchemlett.9b00399 |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|