| Identification | Back Directory | [Name]
4-N-BOC-AMINO-CYCLOHEXANOL | [CAS]
224309-64-2 | [Synonyms]
N-4-Boc-aminocyclohexanol
4-(Boc-amino)cyclohexanol
4-N-BOC-AMINO-CYCLOHEXANOL
tert-butyl cyclohexylcarbaMate
tert-Butyl 4-hydroxycyclohexylcarbaMate
4-(tert-Butoxycarbonylamino)cyclohexanol
4-(tert-Butoxycarbonylamino)cyclohexanol >
4-(tert-Butoxycarbonylamino)cyclohexanol
(4-HYDROXY-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
(4-Hydroxycyclohexyl)carbaMic Acid 1,1-DiMethylethyl Ester
CarbaMic acid, N-(4-hydroxycyclohexyl)-, 1,1-diMethylethyl ester
Carbamic acid, (4-hydroxycyclohexyl)-, 1,1-dimethylethyl ester (9CI)
4-[(tert-Butoxycarbonyl)amino]cyclohexanol (Mixture of Diastereomers) | [Molecular Formula]
C11H21NO3 | [MDL Number]
MFCD06658349 | [MOL File]
224309-64-2.mol | [Molecular Weight]
215.29 |
| Chemical Properties | Back Directory | [Melting point ]
170.0 to 174.0 °C | [Boiling point ]
337.7±31.0 °C(Predicted) | [density ]
1.06±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform, Dichloromethane, DMSO, Methanol | [form ]
Solid | [pka]
12.36±0.40(Predicted) | [color ]
White | [InChI]
InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-8-4-6-9(13)7-5-8/h8-9,13H,4-7H2,1-3H3,(H,12,14) | [InChIKey]
DQARDWKWPIRJEH-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)NC1CCC(O)CC1 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N | [Risk Statements ]
22-50 | [Safety Statements ]
61 | [WGK Germany ]
WGK 3 | [HS Code ]
2924.29.9500 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Acute 1 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Synthesis Reference(s)]
Chemistry Letters, 22, p. 1273, 1993
Tetrahedron Letters, 33, p. 2677, 1992 DOI: 10.1016/S0040-4039(00)79055-1 | [Synthesis]
General procedure: di-tert-butyl dicarbonate (4.087 mL, 21.01 mmol) and diisopropylethylamine (2.87 mL, 17.4 mmol) were dissolved in anhydrous THF (60 mL) under nitrogen protection. Subsequently, (1R,4R)-4-aminocyclohexanol (2.00 g, 17.4 mmol) was slowly added to this solution. The reaction mixture was stirred at room temperature (25°C) for 4 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was concentrated to dryness in a rotary evaporator. The residue was dried overnight under high vacuum to afford 4-(Boc-amino)cyclohexanol as a white solid (3.49 g, 87.0% yield). The product could be used in subsequent reactions without further purification. | [References]
[1] Patent: WO2017/100662, 2017, A1. Location in patent: Page/Page column 103; 123
[2] Patent: WO2013/107405, 2013, A1. Location in patent: Page/Page column 48-49
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 7, p. 2017 - 2021
[4] Patent: US5516806, 1996, A
[5] Patent: WO2013/107291, 2013, A1. Location in patent: Page/Page column 63; 64 |
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