| Identification | Back Directory | [Name]
2-Propenamide, N-[3-[[2-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]- | [CAS]
2243136-03-8 | [Synonyms]
JAK3/BTK-IN-6
2-Propenamide, N-[3-[[2-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]- | [Molecular Formula]
C21H17BF3N5O3 | [MOL File]
2243136-03-8.mol | [Molecular Weight]
455.2 |
| Hazard Information | Back Directory | [Uses]
JAK3/BTK-IN-6 (compound 14h) is a potent BTK and JAK3 dual inhibitor, with IC50 values of 0.6 and 0.4 nM, respectively. JAK3/BTK-IN-6 shows good metabolic stability in human liver microsome. JAK3/BTK-IN-6 can be used for hematological and immune diseases research[1]. | [IC 50]
JAK3: 0.4 nM (IC50); JAK2: 657.9 nM (IC50); JAK1: >1000 nM (IC50); Tyk2: >1000 nM (IC50) | [References]
[1] Ren J, et al. Design and synthesis of boron-containing diphenylpyrimidines as potent BTK and JAK3 dual inhibitors. Bioorg Med Chem. 2020 Jan 15;28(2):115236. DOI:10.1016/j.bmc.2019.115236 |
|
|