| Chemical Properties | Back Directory | [Boiling point ]
768.666±70.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.325±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
6.441±0.10(predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
BET-IN-14 is an orally active pan BET inhibitor (IC50: 5.35 nM). BET-IN-14 has anti-cancer activity[1]. | [in vivo]
BET-IN-14 (Compound 171) (50 and 100 mg/kg, p.o., qd) inhibits tumor growth in MV-4-11 xenograft[1].
| Animal Model: | Human MV-4-11 xenografts in Balb/c nude mice[1] | | Dosage: | 50 and 100 mg/kg | | Administration: | p.o., qd | | Result: | Inhibited tumor growth by 60.36%. |
| [References]
[1] Damaneh MS, et al. A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis induction. Invest New Drugs. 2020 Jun;38(3):700-713. DOI:10.1007/s10637-019-00818-z |
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