| Identification | Back Directory | [Name]
4-[[(7S)-1-[3-[[(2,2-Difluoro-1,3-benzodioxol-5-yl)methylamino]carbonyl]phenyl]-4,5,6,7-tetrahydro-3-(trifluoromethyl)-1H-indazol-7-yl]oxy]benzoic acid | [CAS]
2244458-40-8 | [Synonyms]
ARN23765
4-[[(7S)-1-[3-[[(2,2-Difluoro-1,3-benzodioxol-5-yl)methylamino]carbonyl]phenyl]-4,5,6,7-tetrahydro-3-(trifluoromethyl)-1H-indazol-7-yl]oxy]benzoic acid | [Molecular Formula]
C30H22F5N3O6 | [MOL File]
2244458-40-8.mol | [Molecular Weight]
615.51 |
| Hazard Information | Back Directory | [Uses]
ARN23765 is a corrector for F508del-CFTR with an EC50 of 38 pM in human bronchial epithelial cells. ARN23765 improves the maturation and function of F508del-CFTR on the cell membrane, affects the ions transport and secretion, and corrects the pathological mechanism of cystic fibrosis (CF)[1]. | [References]
[1] Pedemonte N, et al., Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel. Sci Adv. 2020 Feb 21;6(8):eaay9669. DOI:10.1126/sciadv.aay9669 |
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