| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 4-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)- | [CAS]
2244520-92-9 | [Synonyms]
4-fluoro-2-(1-methyl-2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
4-Fluoro-2-(1-methyl-2,6-dioxopiperidin3-yl)isoindoline-1,3-dione
1H-Isoindole-1,3(2H)-dione, 4-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-
4-fluoro-2-(1-methyl-2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione | [Molecular Formula]
C14H11FN2O4 | [MDL Number]
MFCD34563580 | [MOL File]
2244520-92-9.mol | [Molecular Weight]
290.25 |
| Chemical Properties | Back Directory | [Boiling point ]
487.4±40.0 °C(Predicted) | [density ]
1.520±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
-2.61±0.40(Predicted) | [color ]
Off-white to gray |
| Hazard Information | Back Directory | [Uses]
N-Me-Thalidomide 4-fluoride is a ligand for E3 ligase, used for the synthesis of Anti-inflammatory agent 70 (HY-157570)[1]. | [IC 50]
Cereblon | [References]
[1] Liu J, et al. Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy. J Med Chem. 2022 May 12;65(9):6593-6611. DOI:10.1021/acs.jmedchem.1c01948 |
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