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2244579-87-9

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2244579-87-9 Structure

2244579-87-9 Structure
IdentificationBack Directory
[Name]

C2
[CAS]

2244579-87-9
[Synonyms]

Ec2la
CB2R PAM
CB2R PAM,CB-2R PAM
Cycloheptanecarboxamide, N-[5-bromo-1-[(4-fluorophenyl)methyl]-1,2-dihydro-4-methyl-2-oxo-3-pyridinyl]-
[Molecular Formula]

C21H24BrFN2O2
[MDL Number]

MFCD31811635
[MOL File]

2244579-87-9.mol
[Molecular Weight]

435.33
Chemical PropertiesBack Directory
[Boiling point ]

572.4±50.0 °C(Predicted)
[density ]

1.40±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

12.01±0.20(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain[1].
[in vivo]

CB2R PAM (1-20 mg/kg; p.o.) displays antinociceptive activity[1].

Animal Model:Male CD-1 albino mice (Oxaliplatin-induced neuropathic pain model)[1]
Dosage:1, 5, 10, 20 mg/kg
Administration:P.o.
Result:Significantly increased licking latency in the animals starting from 5 mg/kg.
[IC 50]

cannabinoid type-2 receptors
[storage]

Store at -20°C
[References]

[1] Gado F, et al. Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief. J Med Chem. 2019;62(1):276-287. DOI:10.1021/acs.jmedchem.8b00368
Spectrum DetailBack Directory
[Spectrum Detail]

C2(2244579-87-9)1HNMR
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