| Identification | Back Directory | [Name]
C2 | [CAS]
2244579-87-9 | [Synonyms]
Ec2la
CB2R PAM
CB2R PAM,CB-2R PAM
Cycloheptanecarboxamide, N-[5-bromo-1-[(4-fluorophenyl)methyl]-1,2-dihydro-4-methyl-2-oxo-3-pyridinyl]- | [Molecular Formula]
C21H24BrFN2O2 | [MDL Number]
MFCD31811635 | [MOL File]
2244579-87-9.mol | [Molecular Weight]
435.33 |
| Chemical Properties | Back Directory | [Boiling point ]
572.4±50.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
12.01±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain[1]. | [in vivo]
CB2R PAM (1-20 mg/kg; p.o.) displays antinociceptive activity[1]. | Animal Model: | Male CD-1 albino mice (Oxaliplatin-induced neuropathic pain model)[1] | | Dosage: | 1, 5, 10, 20 mg/kg | | Administration: | P.o. | | Result: | Significantly increased licking latency in the animals starting from 5 mg/kg.
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| [IC 50]
cannabinoid type-2 receptors | [storage]
Store at -20°C | [References]
[1] Gado F, et al. Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief. J Med Chem. 2019;62(1):276-287. DOI:10.1021/acs.jmedchem.8b00368 |
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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