| Identification | Back Directory | [Name]
3,3,4-Trimethyl-1-[1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl]-4-penten-1-one | [CAS]
2244599-90-2 | [Synonyms]
3,3,4-Trimethyl-1-[1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl]-4-penten-1-one | [Molecular Formula]
C22H29NO2 | [MOL File]
2244599-90-2.mol | [Molecular Weight]
339.47 |
| Hazard Information | Back Directory | [Description]
A-834735 is an indole-derived cannabinoid (CB) with a 3-tetramethylcyclopropylmethanone substituent. It acts as a full agonist at both the central CB1 and peripheral CB2 receptors in rat with Ki values of 4.6 and 0.31 nM, respectively, and EC50 values of 12 and 0.21 nM, respectively.1 A-834735 readily crosses the blood-brain barrier, dose-dependently reversing thermal hyperalgesia without adverse side effects in a rat neuropathic pain model.1 A-834735 degradant is a common impurity observed during GC-MS analysis of samples containing A-834735. The opened ring of the degradant is presumed to be produced during heating of A-834735. This structure gives rise to a prominent fragment ion that is 15 amu greater than the base peak of A-834735. This pattern is consistent with McLafferty rearrangement of the degradant which does not occur with the parent compound.2 | [References]
1. Chin, C.L., Tovcimak, A.E., Hradil, V.P., et al. Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI Br. J. Pharmacol. 153(2),367-379(2008).
2. McLafferty, F.W. Mass spectrometric analysis. Molecular rearrangements Anal. Chem. 31(1),82-87(1959). |
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