| Identification | Back Directory | [Name]
Quinoline, 4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethoxy]-5,7-dimethoxy-2-(4-propoxyphenyl)- | [CAS]
2244991-17-9 | [Synonyms]
SARS-CoV-2-IN-19
Quinoline, 4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethoxy]-5,7-dimethoxy-2-(4-propoxyphenyl)- | [Molecular Formula]
C33H38N2O6 | [MOL File]
2244991-17-9.mol | [Molecular Weight]
558.66 |
| Hazard Information | Back Directory | [Uses]
SARS-CoV-2-IN-19 (Compound 6g) is a potent inhibitor of SARS-CoV-2 with an EC50 of 8.8 μM. SARS-CoV-2-IN-19 shows potent activity against SARS-CoV-2 helicase (nsp13), a highly conserved enzyme, highlighting a potentiality against emerging HCoVs outbreaks. SARS-CoV-2-IN-19 has the potential for the research of infection diseases[1]. | [References]
[1] Nizi MG, et al. Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity. ACS Med Chem Lett. 2022 May 3;13(5):855-864. DOI:10.1021/acsmedchemlett.2c00123 |
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