| Identification | Back Directory | [Name]
GSK2807 Trifluoroacetate | [CAS]
2245255-66-5 | [Synonyms]
CS-2876
GSK2807 Trifluoroacetate | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C21H33F3N8O7 | [MDL Number]
MFCD31715435 | [MOL File]
2245255-66-5.mol | [Molecular Weight]
566.54 |
| Chemical Properties | Back Directory | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO:250.0(Max Conc. mg/mL);441.28(Max Conc. mM)
Water:50.0(Max Conc. mg/mL);88.26(Max Conc. mM) | [form ]
Solid | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
GSK2807 Trifluoroacetate is a potent, selective and SAM-competitive inhibitor of SMYD3, with a Ki of 14 nM and an IC50 of 130 nM[1][2]. | [IC 50]
SMYD3: 14 nM (Ki); SMYD3: 130 nM (IC50) | [References]
[1] Van Aller GS, et al. Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets. Structure. 2016 May 3;24(5):774-781. DOI:10.1016/j.str.2016.03.010
[2] Kaniskan Hü, et al. Inhibitors of Protein Methyltransferases and Demethylases. Chem Rev. 2018 Feb 14;118(3):989-1068. DOI:10.1021/acs.chemrev.6b00801 |
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| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|