| Identification | Back Directory | [Name]
MLCK INHIBITOR PEPTIDE 18 | [CAS]
224579-74-2 | [Synonyms]
H-RKKYKYRRK-NH2
MLCK INHIBITOR PEPTIDE 18
MLCK inhibitor peptide 18,RKKYKYRRK, >98%
MYOSIN LIGHT CHAIN KINASE INHIBITOR PEPTIDE 18
L-Lysinamide, L-arginyl-L-lysyl-L-lysyl-L-tyrosyl-L-lysyl-L-tyrosyl-L-arginyl-L-arginyl- | [Molecular Formula]
C60H105N23O11 | [MDL Number]
MFCD04974185 | [MOL File]
224579-74-2.mol | [Molecular Weight]
1324.62 |
| Chemical Properties | Back Directory | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at -20°C | [solubility ]
DMF: 12 mg/mL; DMSO: 5 mg/mL; Ethanol: 12 mg/mL; PBS (pH 7.2): 5 mg/mL | [form ]
A crystalline solid | [pka]
9.82±0.15(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2 |
| Hazard Information | Back Directory | [Uses]
MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations. | [Biological Activity]
Cell permeable: yes''Primary Target
Mlck''Product does not compete with ATP.''Reversible: no''Target IC50: 50 nM against MLCK | [IC 50]
CaMK II | [storage]
Store at -20°C | [References]
[1] Lukas TJ, et al. Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. J Med Chem. 1999 Mar 11;42(5):910-9. |
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