2247210-09-7

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2247210-09-7 Structure

Identification	Back Directory
[Name] YF438
[CAS] 2247210-09-7
[Synonyms] YF438 Heptanediamide, N7-hydroxy-N1-(4-methoxyphenyl)-N1-[(5-phenyl-1,2,4-oxadiazol-3-yl)methyl]-
[Molecular Formula] C23H26N4O5
[MOL File] 2247210-09-7.mol
[Molecular Weight] 438.48

Chemical Properties	Back Directory
[density ] 1.266±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[pka] 9.462±0.20(predicted)

Hazard Information	Back Directory
[Uses] YF438 is an HDAC inhibitor with effective anticancer activity both in vitro and in vivo. YF438 inhibits the growth and metastasis of triple-negative breast cancer (TNBC) cells by blocking the interaction between HDAC and MDM2, inducing the dissociation of MDM2-MDMX, and promoting the degradation of MDM2[1].
[References] [1] Shan P, et al. Alteration of MDM2 by the Small Molecule YF438 Exerts Antitumor Effects in Triple-Negative Breast Cancer. Cancer Res. 2021 Aug 1;81(15):4027-4040. DOI:10.1158/0008-5472.CAN-20-0922

2247210-09-7 suppliers list

Company Name:	Shanghai Beckham Medical Technology Co., Ltd
Tel:	021-13816613772 13816613772
Website:	https://www.chemicalbook.com/ShowSupplierProductsList16976/0.htm

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