| Chemical Properties | Back Directory | [Boiling point ]
688.0±55.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
9.87±0.35(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
IUN91978, also known as NPB, is a specific inhibitor of the phosphorylation of human BCL-2-associated death promoter (hBAD) specifically on Ser99, thereby exerting its effect independently of AKT and other kinase activities despite the demonstration of AKT-mediated BAD-Ser99 phosphorylation. NPB was reported by Pandey V et al in PNAS. 2018, 115(44):E10505-E10514. This product has no formal name at the moment. | [Uses]
NPB is a specific and potent inhibitor of BAD phosphorylation at Ser99, with an IC50 of 0.41 μM[1]. | [References]
[1] Pandey V, et al. Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation. Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):E10505-E10514. DOI:10.1073/pnas.1804897115 |
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