| Identification | Back Directory | [Name]
Thieno[2,3-c]pyridine-6(5H)-carboxamide, 3-cyano-4,7-dihydro-N-(4-methoxyphenyl)-2-[[(1-methyl-1H-pyrazol-4-yl)carbonyl]amino]- | [CAS]
2248552-86-3 | [Synonyms]
STAT3-IN-13
Thieno[2,3-c]pyridine-6(5H)-carboxamide, 3-cyano-4,7-dihydro-N-(4-methoxyphenyl)-2-[[(1-methyl-1H-pyrazol-4-yl)carbonyl]amino]- | [Molecular Formula]
C21H20N6O3S | [MOL File]
2248552-86-3.mol | [Molecular Weight]
436.49 |
| Chemical Properties | Back Directory | [Boiling point ]
667.2±55.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.62±0.70(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Uses]
STAT3-IN-13 (compound 6f) is a potent STAT3 inhibitor. STAT3-IN-13 has anti-proliferative effects and binds to the STAT3 SH2 domain with a KD of 0.46 μM. STAT3-IN-13 inhibits the phosphorylation of STAT3 Y705 and downstream target gene expression. STAT3-IN-13 induces apoptosis in vitro and suppresses the growth and metastasis of tumor in vivo. STAT3-IN-13 can be used for cancer research[1]. | [in vivo]
STAT3-IN-13 (compound 6f) (10-20 mg/kg; i.p.; twice daily, for 4 weeks; nude mice) blocks osteosarcoma growth and metastasis in vivo[1]. | Animal Model: | Nude mice | | Dosage: | 10 and 20 mg/kg | | Administration: | Intraperitoneal injection; twice daily, for 4 weeks | | Result: | Suppressed tumor weight at a dose of 10 mg/kg. |
| [References]
[1] Jin W, et, al. Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis. J Med Chem. 2022 May 12;65(9):6710-6728. DOI:10.1021/acs.jmedchem.2c00004 |
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