ChemicalBook--->CAS DataBase List--->2249722-58-3

2249722-58-3

2249722-58-3 Structure

2249722-58-3 Structure
IdentificationBack Directory
[Name]

Urabrelimab
[CAS]

2249722-58-3
[Synonyms]

Urabrelimab
Urabrelimab (anti-CD47)
Research Grade Urabrelimab
Research Grade Urabrelimab(DHG17602)
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Uses]

Urabrelimab (SRF231) is a fully human anti-CD47 monoclonal antibody that blocks the CD47-SIRP interaction[1].
[in vivo]

Urabrelimab (SRF231) administration leads to profound tumor growth inhibition in models of multiple myeloma, diffuse large B cell lymphoma and Burkitt's lymphoma as a single agent and in combination with opsonizing antibodies. In the Raji xenograft model, single agent therapy leads to 112% tumor growth inhibition[1].

[References]

[1] Holland P M, et al. CD47 monoclonal antibody SRF231 is a potent inducer of macrophage-mediated tumor cell phagocytosis and reduces tumor burden in murine models of hematologic malignancies. 2016.
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