| Identification | Back Directory | [Name]
BocNH-PEG3-CH2CH2COONHS | [CAS]
2250216-93-2 | [Synonyms]
Boc-NH-PEG3-NHS ester
BocNH-PEG3-CH2CH2COONHS
2,5-Dioxopyrrolidin-1-yl 2,2-dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azaheptadecan-17-oate | [Molecular Formula]
C18H30N2O9 | [MDL Number]
MFCD31811545 | [MOL File]
2250216-93-2.mol | [Molecular Weight]
418.44 |
| Chemical Properties | Back Directory | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
Storage temp. -20°C | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Liquid | [pka]
12.22±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
t-Boc-N-amido-PEG3-NHS ester is a PEG linker containing an NHS ester and a t-Boc protected amine group. The hydrophilic PEG spacer increases the solubility of compounds in aqueous media. The t-Boc group can be deprotected under mild acidic conditions to form a free amine. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | [Uses]
Boc-NH-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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