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2250411-18-6

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2250411-18-6 Structure

2250411-18-6 Structure
IdentificationBack Directory
[Name]

Propargyl-PEG11-methane
[CAS]

2250411-18-6
[Synonyms]

Propargyl-PEG11-methane
[Molecular Formula]

C26H50O12
[MDL Number]

MFCD31654030
[MOL File]

2250411-18-6.mol
[Molecular Weight]

554.67
Chemical PropertiesBack Directory
[Boiling point ]

570.0±45.0 °C(Predicted)
[density ]

1.071±0.06 g/cm3(Predicted)
Hazard InformationBack Directory
[Description]

Propargyl-PEG12-methane is a PEG linker that can react with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry to form a stable triazole linkage. The PEG chain enhances the solubility of the molecule in aqueous media.
[Uses]

Propargyl-PEG11-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG11-methane is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Spectrum DetailBack Directory
[Spectrum Detail]

Propargyl-PEG11-methane(2250411-18-6)1HNMR
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