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IR820-PTX, an IR-820 (HY-136886)-Paclitaxel (HY-B0015) conjugate, is an amphipathic small molecule prodrug. IR820-PTX effectively inhibits tumor growth via combined photothermal therapy (PTT) and chemotherapy[1][2]. | [References]
[1] Zhang D, et al. pH- and Enzyme-Sensitive IR820-Paclitaxel Conjugate Self-Assembled Nanovehicles for Near-Infrared Fluorescence Imaging-Guided Chemo-Photothermal Therapy. ACS Appl Mater Interfaces. 2018 Sep 12;10(36):30092-30102. DOI:10.1021/acsami.8b09098
[2] Yu-Xia Luan, et al. Preparation method and application of amphiphilic small molecule prodrug of ir820-ptx combined with photothermal therapy and chemotherapy and its nanoparticles. CN108727353B. |
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