| Identification | Back Directory | [Name]
2(1H)-Quinazolinone, 6-chloro-7-(2-fluoro-6-hydroxyphenyl)-1-[2-(1-methylethyl)phenyl]-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-, (1R)- | [CAS]
2253119-24-1 | [Synonyms]
KRAS G12C inhibitor 47
2(1H)-Quinazolinone, 6-chloro-7-(2-fluoro-6-hydroxyphenyl)-1-[2-(1-methylethyl)phenyl]-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-, (1R)- | [Molecular Formula]
C30H28ClFN4O3 | [MOL File]
2253119-24-1.mol | [Molecular Weight]
547.03 |
| Hazard Information | Back Directory | [Uses]
KRAS G12C inhibitor 47 (compound 8-1-1) is a potent KRAS G12C inhibitor with an IC50 of 0.172 μM. KRAS G12C inhibitor 47 shows p-ERK inhibition activities with IC50s of 0.046, 69.8 μM in MIA PaCA-2, A549 cells, respectively. KRAS G12C inhibitor 47 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. | [IC 50]
KRas G12C: 0.172 μM (IC50) | [References]
[1] Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2 |
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