| Hazard Information | Back Directory | [Uses]
Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of CD40 and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity[1]. | [in vivo]
Tecaginlimab (0.0008-0.2 μg/mL; 4 d) enhances tumor-infiltrating lymphocyte expansion ex vivo[1].
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CD40; 4-1BB | [References]
[1] Muik A, et, al. DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity. J Immunother Cancer. 2022 Jun;10(6):e004322. DOI:10.1136/jitc-2021-004322 |
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