| Identification | Back Directory | [Name]
Prosta-5,13-dien-1-oic-17,17,18,18,19,19,20,20,20-d9 acid, 9,15-dihydroxy-11-oxo-, (5Z,9α,13E,15S)- | [CAS]
2254642-52-7 | [Synonyms]
Prosta-5,13-dien-1-oic-17,17,18,18,19,19,20,20,20-d9 acid, 9,15-dihydroxy-11-oxo-, (5Z,9α,13E,15S)- | [Molecular Formula]
C20H32O5 | [MOL File]
2254642-52-7.mol | [Molecular Weight]
352.47 |
| Hazard Information | Back Directory | [Uses]
Prostaglandin D2-d9 is the deuterium labeled Prostaglandin D2. Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3]. | [IC 50]
DP | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Suzuki F, et al. Transport of prostaglandin D2 into brain. Brain Res. 1986 Oct 22;385(2):321-8. DOI:10.1016/0006-8993(86)91079-6
[3] Zhang BJ, et al. Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 in mice. Acta Pharmacol Sin. 2017 Apr;38(4):469-476. DOI:10.1038/aps.2016.140
[4] Kida T, et al. Prostaglandin D2 Attenuates NSC 125066-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS One. 2016 Dec 19;11(12):e0167729. DOI:10.1371/journal.pone.0167729 |
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