| Identification | Back Directory | [Name]
Naphth[2,3-d]isoxazole-4,9-dione, 3-[(3,4-dimethoxyphenyl)methyl]-5-hydroxy- | [CAS]
2256751-16-1 | [Synonyms]
Naphth[2,3-d]isoxazole-4,9-dione, 3-[(3,4-dimethoxyphenyl)methyl]-5-hydroxy- | [Molecular Formula]
C20H15NO6 | [MOL File]
2256751-16-1.mol | [Molecular Weight]
365.34 |
| Chemical Properties | Back Directory | [Boiling point ]
607.1±55.0 °C(predicted) | [density ]
1.400±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
5.95±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
STAT3-IN-29 (Compound B20) is an inhibitor for STAT3. STAT3-IN-29 inhibits the proliferation of HaCaT cell with IC50 of 0.09 μM, ameliorates the IMQ-induced psoriasis in mouse models[1]. | [IC 50]
STAT3 | [References]
[1] Chen L, et al. Synthesis and biological evaluation of novel isoxazoloquinone derivatives as potent STAT3-targeting antipsoriasis agents[J]. Bioorganic Chemistry, 2024: 107617. |
|
|