2258671-41-7

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2258671-41-7 Structure

Identification	Back Directory
[Name] 1H-Pyrrolo[3,2-b]pyridine-1-carboxylic acid, 6-[2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl]-2,3-dihydro-, tetrahydro-2H-pyran-4-yl ester
[CAS] 2258671-41-7
[Synonyms] 1H-Pyrrolo[3,2-b]pyridine-1-carboxylic acid, 6-[2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl]-2,3-dihydro-, tetrahydro-2H-pyran-4-yl ester
[Molecular Formula] C24H25N5O4
[MOL File] 2258671-41-7.mol
[Molecular Weight] 447.49

Chemical Properties	Back Directory
[density ] 1.53±0.1 g/cm3(Predicted)
[form ] Solid
[pka] 10.51±0.50(Predicted)
[color ] Off-white to light yellow

Hazard Information	Back Directory
[Uses] Zharp1-211 is a potent inhibitor of RIPK1 kinase. Zharp1-211 significantly reduces the expression of JAK/STAT1-mediated chemokines and MHC class II molecules in intestinal epithelial cells[1].
[References] [1] Yu X, et al. A novel RIPK1 inhibitor reduces GVHD in mice via a nonimmunosuppressive mechanism that restores intestinal homeostasis. Blood. 2023 Mar 2;141(9):1070-1086. DOI:10.1182/blood.2022017262

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