| Identification | Back Directory | [Name]
7-Quinazolinecarboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-1,2,3,4-tetrahydro-3,4-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-, (4S)- | [CAS]
2259308-68-2 | [Synonyms]
STING agonist-11
7-Quinazolinecarboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-1,2,3,4-tetrahydro-3,4-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-, (4S)- | [Molecular Formula]
C25H20ClF4N3O2 | [MOL File]
2259308-68-2.mol | [Molecular Weight]
505.89 |
| Hazard Information | Back Directory | [Uses]
STING agonist-11 (Compound 92) is a potent small molecule cyclic urea activator of STING with EC50 of 18 nM. Activation of STING is a highly promising approach in immunotherapy[1]. | [References]
[1] Sourav Basu, et al. The discovery of potent small molecule cyclic urea activators of STING. Eur J Med Chem. 2022 Feb 5;229:114087. DOI:10.1016/j.ejmech.2021.114087 |
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