| Chemical Properties | Back Directory | [Boiling point ]
531.079±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.500±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
Methanol: 10 mg/ml | [pka]
1.480±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
DXR-IN-2 is a 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) inhibitor and an antimalarial agent (IC50: 0.1062 μM for Plasmodium falciparum DXR and 0.369 μM for Plasmodium falciparum). DXR-IN-2 inhibits Plasmodium falciparum growth by suppressing the methyl erythritol phosphate (MEP) pathway via DXR[1]. | [References]
[1] Wang X, et al. MEPicides: α,β-unsaturated Fosmidomycin N-Acyl Analogs as Efficient Inhibitors of Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate reductoisomerase. ACS Infect Dis. 2023, 9(7):1387-1395. DOI:10.1021/acsinfecdis.3c00132 |
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