| Identification | Back Directory | [Name]
Ethanaminium, 2-[[[[(2S,3R,4E)-2-amino-3-hydroxy-4-octadecen-1-yl-16,16,17,17,18,18,18-d7]oxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt | [CAS]
2260670-14-0 | [Synonyms]
Sphingosylphosphorylcholine-d7
Ethanaminium, 2-[[[[(2S,3R,4E)-2-amino-3-hydroxy-4-octadecen-1-yl-16,16,17,17,18,18,18-d7]oxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt | [Molecular Formula]
C23H49N2O5P | [MOL File]
2260670-14-0.mol | [Molecular Weight]
464.63 |
| Hazard Information | Back Directory | [Uses]
Sphingosylphosphorylcholine-d7 is the deuterium labeled Sphingosylphosphorylcholine (HY-132187)[1]. | [Biological Activity]
Lyso-sphingomyelin (Lyso SM) or sphingosylphosphorylcholine (SPC) serves as a multifunctional bioactive sphingolipid in cardiovascular systemimmune systemcentral nervous system and skin. It has a potential to regulate cell proliferationmigrationdifferentiationmetabolism and apoptosis. Patients with pathological conditions such as atopic dermatitisNiemann-Pick disease (NPD) and cancer show considerably higher levels of Lyso SM.''Lysosphingolipids serves as a marker for many sphingolipidoses. Sphingosylphosphorylcholine serves as a bioactive lipid in some tissues and immune system. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110 |
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Merck KGaA
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www.sigmaaldrich.cn |
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