| Identification | Back Directory | [Name]
(1R)-3-(3,4-dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate | [CAS]
2265886-81-3 | [Synonyms]
(1R)-3-(3,4-dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate | [Molecular Formula]
C59H73N5O14 | [MOL File]
2265886-81-3.mol | [Molecular Weight]
1076.25 |
| Chemical Properties | Back Directory | [Boiling point ]
1157.8±65.0 °C(Predicted) | [density ]
1.250±0.06 g/cm3(Predicted) | [solubility ]
DMSO:107.62(Max Conc. mg/mL);100.0(Max Conc. mM) | [form ]
Solid | [pka]
10.81±0.40(Predicted) | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Description]
dTAG-47 is a degrader targeting mutant FKBP12F36V fusion proteins. It comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a cereblon-binding ligand. Application of dTAG-47 induces rapid, reversible and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo. dTAG-47 is generalizable to a range of fusion proteins. It is useful as an alternative to genetic methods for target validation. | [Uses]
dTAG-47, heterobifunctional dTAG molecule, targets mutant FKBP12 (FKBP12F36V). FKBP12F36V serves as a degradation tag (dTAG) and is fused to a protein of interest. dTAG-47 can be used for the research of basal-like breast cancers (BBC)[1]. | [storage]
Store at -20°C | [References]
[1] Hai-Tsang Huang, et al. MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife. 2017 Sep 19;6:e26693. DOI:10.7554/eLife.26693 |
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| Company Name: |
ChemShuttle, Inc.
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0510-83588313-811 18800520310 |
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https://www.jiehuapharma.com/ |
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