| Identification | Back Directory | [Name]
9H-Purine-9-ethanamine, 6-amino-N-(2,2-dimethylpropyl)-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-, hydrochloride (1:2) | [CAS]
2267287-26-1 | [Synonyms]
Icapamespib HCl
9H-Purine-9-ethanamine, 6-amino-N-(2,2-dimethylpropyl)-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-, hydrochloride (1:2) | [Molecular Formula]
C19H24ClIN6O2S | [MOL File]
2267287-26-1.mol | [Molecular Weight]
562.86 |
| Hazard Information | Back Directory | [Uses]
Icapamespib hydrochloride (PU-HZ151) is a potent HSP90 inhibitor with an EC50 of 5?nM. Icapamespib hydrochloride is able to cross blood-brain barrier[1]. | [References]
[1] Bolaender A, et al. Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system. Nat Commun. 2021;12(1):4669. Published 2021 Aug 3. DOI:10.1038/s41467-021-24821-2 |
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