| Identification | Back Directory | [Name]
5H-Pyrido[4,3-b]indole-7-propanamide, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]- | [CAS]
2267290-96-8 | [Synonyms]
5H-Pyrido[4,3-b]indole-7-propanamide, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]- | [Molecular Formula]
C33H34N6O7 | [MOL File]
2267290-96-8.mol | [Molecular Weight]
626.66 |
| Chemical Properties | Back Directory | [Boiling point ]
977.2±65.0 °C(Predicted) | [density ]
1.416±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.74±0.40(Predicted) | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Description]
QC-01-175 targets ZFP91, ZN653, ZN827 also degraded at 4 h, 1 μM in patient iPSC derived FTD neurons harboring MAPT A152T mutation. | [Uses]
QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 (HY-W453397); Black: linker NH2-PEG3 (HY-W007545); Blue: ligand for E3 ligase Pomalidomide (HY-10984))[1][2]. | [References]
[1] Silva MC, et al., Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife. 2019 Mar 25;8:e45457. DOI:10.7554/eLife.45457
[2] Tiziana Petrozziello, et al. Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis. Mol Neurobiol. 2022 Jan;59(1):683-702. DOI:10.1007/s12035-021-02557-w |
|
| Company Name: |
DC Chemicals
|
| Telephone: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0_EN.htm |
| Company Name: |
EMERTH
|
| Telephone: |
19011298796 19011298796 |
| Website: |
|
|