| Identification | Back Directory | [Name]
Datopotamab | [CAS]
2267989-53-5 | [Synonyms]
Datopotamab
Datopotamab (anti-TROP2)
Research Grade Datopotamab (DHC43302) |
| Hazard Information | Back Directory | [Uses]
Datopotamab (CDP7657) is a humanized anti trophoblast cell surface antigen 2 (TROP2) antibody. Datopotamab can generate antibody drug conjugates (ADC) (HY-141598) with DNA topoisomerase I inhibitor Deruxtecan (HY-13631E). Datopotamab can be used in the study of triple negative breast cancer and non-small cell lung cancer[1]. | [in vivo]
Datopotamab deruxtecan (Dato-DXd; 6 mg/kg) shows potent antitumor activity with tumor regression in several TROP2-expressing xenograft tumors including NSCLC patient-derived xenograft (PDX) models. Safety profiles of Datopotamab deruxtecan in rats and cynomolgus monkeys are acceptable[1]. | [References]
[1] Okajima D, et al. Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells. Mol Cancer Ther. 2021 Dec;20(12):2329-2340. DOI:10.1158/1535-7163.MCT-21-0206
[2] Daisuke Okajima, et al. Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells. Mol Cancer Ther. 2021 Aug 19. DOI:10.1158/1535-7163.MCT-21-0206 |
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| Company Name: |
Biolab Reagents
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18108604356 18108604356 |
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www.biolabreagent.com/ |
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