| Identification | Back Directory | [Name]
6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol | [CAS]
226907-52-4 | [Synonyms]
CL087
1V136
SM360320
SM-360320?(Synonyms: CL-087)
Toll-Like Receptor 7 Ligand II
6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol
6-Amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-8H-purin-8-one
8H-Purin-8-one, 6-amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-
TLR7,Inhibitor,Th1,Toll-like Receptor (TLR),SM360320,antitumor effect,oral,DNA vaccines,inhibit | [Molecular Formula]
C15H17N5O3 | [MDL Number]
MFCD21337856 | [MOL File]
226907-52-4.mol | [Molecular Weight]
315.33 |
| Chemical Properties | Back Directory | [density ]
1.356 | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response[1]. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity[2]. | [storage]
Store at -20°C | [References]
[1] Dharmapuri S, et al. An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models. Cancer Gene Ther. 2009;16(5):462-472. DOI:10.1038/cgt.2008.91
[2] Lee J, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006;103(6):1828-1833. DOI:10.1073/pnas.0510801103 |
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