| Identification | Back Directory | [Name]
LB42908 | [CAS]
226927-89-5 | [Synonyms]
LB42908
LB42908
(LB 42908
Methanone, [1-[[1-(1,3-benzodioxol-5-ylmethyl)-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl](4-methyl-1-piperazinyl)- | [Molecular Formula]
C32H31N5O3 | [MOL File]
226927-89-5.mol | [Molecular Weight]
533.62 |
| Hazard Information | Back Directory | [Uses]
LB42908 is a potent, selective and orally active farnesyltransferase inhibitor. LB42908 inhibits farnesylation of H-Ras, K-Ras with IC50 values of 0.9 nM, 2.4 nM for H-Ras, K-Ras, respectively. LB42908 shows antiproliferative activity. LB42908 shows antitumor activity[1]. | [in vivo]
LB42908 (20, 40, 60 mg/kg; p.o.; twice daily for 21 days) inhibits tumor growth in a dose-dependent manner[1]. | [References]
[1] Lee H, et al. A novel class of highly potent, selective, and non-peptidic inhibitor of Ras farnesyltransferase (FTase). Bioorg Med Chem Lett. 2001 Dec 3;11(23):3069-72. DOI:10.1016/s0960-894x(01)00624-2 |
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