| Identification | Back Directory | [Name]
Benzene, 1-(phenylseleno)-4-(trifluoromethyl)- | [CAS]
227010-33-5 | [Synonyms]
LDHA-IN-3
Benzene, 1-(phenylseleno)-4-(trifluoromethyl)- | [Molecular Formula]
C13H9F3Se | [MOL File]
227010-33-5.mol | [Molecular Weight]
301.17 |
| Chemical Properties | Back Directory | [Boiling point ]
306.2±42.0 °C(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (332.04 mM; Need ultrasonic) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase (LDHA) inhibitor (IC50=145.2 nM). LDHA-IN-3 can be used for the research of cancer[1].
PSTMB (0~500 μM; 48 hours; MCF-7 cells) shows cytotoxic effect[1].PSTMB (0.01~1 μM) shows dose-dependent inhibition of LDHA activity. PSTMB (0~0.5 μM) inhibits LDHA activity in Michaelis-Menten and Lineweaver-Burk plots. PSTMB (30 and 50 μM; HT29 cells) induces ROS production and mitochondrial damage[1].PSTMB can bind to LDHA protein efficiently. PSTMB induces the intrinsic pathway-mediated apoptosis of cancer cells via production of mitochondrial ROS[1]. | [References]
[1]. Kim EY, et al. A Novel Lactate Dehydrogenase Inhibitor, 1-(Phenylseleno)-4-(Trifluoromethyl) Benzene, Suppresses Tumor Growth through Apoptotic Cell Death. Sci Rep. 2019;9(1):3969. Published 2019 Mar 8. |
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