| Chemical Properties | Back Directory | [Boiling point ]
668.3±65.0 °C(Predicted) | [density ]
1.214±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Ethanol: Soluble | [form ]
A crystalline solid | [pka]
12.27±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
UAMC-3203 is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM. | [Biological Activity]
UAMC-3203 is a ferroptosis inhibitor with IC50 of 10 nM in IMR-32 neuroblastoma cells. | [in vitro]
UAMC-3203 was incubated with human microsomes or rat microsomes, and the T 1/2 were 20.5 h and 16.5 h, respectively. When co-incubated with mouse microsomes, UAMC-3203 showed relatively poor stability, with a T 1/2 of 3.46 h. | [in vivo]
In mice, UAMC-3203 can significantly reduce the plasma concentration of lactate dehydrogenase. After administration, it is rapidly removed from the blood and enters various tissues. Significant levels of UAMC-3203 were detected in the tissues tested, such as liver, kidney and lung. | [target]
| Target | Value | Ferroptosis
(IMR-32 neuroblastoma cells) | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 10 nM
| [References]
[1] Devisscher L, et al. Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy. J Med Chem. 2018 Nov 21;61(22):10126-10140. DOI:10.1021/acs.jmedchem.8b01299 |
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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