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2275774-60-0

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2275774-60-0 Structure

2275774-60-0 Structure
IdentificationBack Directory
[Name]

BAY 2666605
[CAS]

2275774-60-0
[Synonyms]

BAY 2666605
[Molecular Formula]

C17H12F4N2O2
[MOL File]

2275774-60-0.mol
[Molecular Weight]

352.28
Chemical PropertiesBack Directory
[density ]

1.40±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[form ]

Solid
[pka]

9.07±0.60(Predicted)
[color ]

White to off-white
[InChI]

InChI=1S/C17H12F4N2O2/c1-9-15(22-23-16(24)25-9)11-4-7-13(14(8-11)17(19,20)21)10-2-5-12(18)6-3-10/h2-9H,1H3,(H,23,24)/t9-/m0/s1
[InChIKey]

JNTJTCXFIXNXDV-VIFPVBQESA-N
[SMILES]

O1[C@@H](C)C(C2=CC=C(C3=CC=C(F)C=C3)C(C(F)(F)F)=C2)=NNC1=O
Hazard InformationBack Directory
[Uses]

BAY 2666605 is an orally active PDE3A and PDE3B inhibitor with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 is a PDE3A-SLFN12 complex inducer.
[in vitro]

BAY 2666605 has anticancer effects, potently inhibit brain cancer(especially glioma, more specifically glioblastoma, astrocytoma), breast cancer (especially ductal carcinoma and adenocarcinoma), cervical cancer, AML(especially erythroleucemia), lung cancer(especially NSCLC adenocarcinoma and SCLC), skin cancer(especially melanoma), oesophagus cancer (especially squamous cell carcinoma), ovarian cancer, (especially teratocarcinoma, adenocarcinoma), pancreas cancer and prostatic cancer.
[in vivo]

BAY 2666605 (5 mg/kg; p.o; twice daily) teatment shows anti-tumor efficacy in murine xenotransplantation models of human cancer[1].

[IC 50]

PDE3A: 87 nM (IC50); PDE3B: 50 nM (IC50)
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

BAY 2666605(2275774-60-0)1HNMR
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